Fig. 2

MSC-Sec/CXCR4 NP inhibits osteoclast differentiation and promotes osteogenic proliferation. Cell proliferation for A MSCs and B osteoblasts that were incubated with different numbers of MSC-Sec/CXCR4 NPs. C ALP activity and D Alizarin Red S staining of primary MSCs after incubating with different concentrations of MSC-Sec/CXCR4 NPs for 2 weeks. Scale bar, 1 mm. Quantifying E relative ALP activity and F the amount of Alizarin Red S that stained the mineralized matrix. *p < 0.05, ** p < 0.01 and *** p < 0.001