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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy

Fig. 4

MSC-Sec/CXCR4 NPs reduces OVX-induced osteoporosis in rats. A Schematic showing the design of in vivo experiments in rats with osteoporosis. B Photograph of OVX surgery to induce osteoporosis. C micro-CT images of distal femur after treating with different samples at 4 week and 16 weeks. Quantitative results of D BMD changes and some trabecular parameters, including trabecular bone volume expressed as percentage of E total tissue volume (BV/TV), F trabecular thickness (Tb.Th), and G trabecular separation (Tb.Sp). n = 6 rats per group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001

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Journal of Nanobiotechnology

ISSN: 1477-3155

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