Fig. 10
From: The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery
a The schematic of pH-amplified self-illuminating PCN for detecting sentinel lymph nodes with tumor metastasis in vivo. b The images of fluorescence imaging (up) and luminescence imaging (down) in vivo at tumor and normal sides after subcutaneously injected with PCN6.9. c Representative images of PCN identify metastasis lymph nodes through luminescence and fluorescence in the process of tumor growth. Top: appearance images of different stages of 4T1-GFP subcutaneous tumors. Middle and bottom: Luminescence and fluorescence images of the metastasis lymph nodes in vivo corresponding to the top. Reproduced with permission from [136]. Copyright 2021, Wiley–VCH Verlag GmbH & Co. KGaA, Weinheim