Fig. 5
From: CRISPR/Cas9 delivery by NIR-responsive biomimetic nanoparticles for targeted HBV therapy
In vivo effects of the UCNPs-Cas9@CM on HBV gene editing. A Serum HBV DNA load in HBV-Tg mice sera were measured by qRT-PCR. Levels of HBsAg (B) and HBeAg (C) in mice serum were measured by CLIA. D Representative images of intrahepatic expression levels of HBsAg and HBcAg in HBV-Tg mice after 14 days of different treatments (IHC staining, scale bars: 30 μm). For A–C, data are presented as mean ± SD, n = 3 in each group. ***p < 0.001