Fig. 6

BCG-Nanocage immunization enhance pulmonary Vγ2+ Vδ2+ T cell responses in non-human primates upon Mtb challenge. A Schematic diagram of Mtb challenge in rhesus macaques. Typical flow images for Vγ2+ Vδ2+ T cell level in T cells in PBMC from (B) saline, C BCG-immunized and D BCG-Nanocage-immunized rhesus macaques before and after Mtb infection. E Changes of Vγ2+ Vδ2+ T cell level in T cells in PBMC from saline, BCG-immunized and BCG-Nanocage-immunized rhesus macaques before and after Mtb infection, for saline treated macaques, ^p < 0.05,^^p < 0.01, for BCG vaccined macaques, #p < 0.05, for BCG-Nanocage vaccined macaques, *p < 0.05. Typical flow images for Vγ2+ Vδ2+ T cell level in T cells in bronchoalveolar lavage (BAL) from (F) saline, G BCG-immunized and H BCG-Nanocage-immunized rhesus macaques before and after Mtb infection. I Changes of Vγ2+ Vδ2+ T cell level in T cells in BAL from saline, BCG-immunized and BCG-Nanocage-immunized rhesus macaques before and after Mtb infection, for saline treated macaques, ^p < 0.05, for BCG vaccined macaques, #p < 0.05, ##p < 0.01, for BCG-Nanocage vaccined macaques, *p < 0.05, **p < 0.01