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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Nanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection

Fig. 7

BCG-Nanocage immunization induce rapid pulmonary Th1/Th1-like responses in non-human primates upon Mtb challenge. Typical flow images for IFN-γ + CD4 + Th1 effector cells in the T cells of bronchoalveolar lavage (BAL) from (A) saline, B BCG-immunized and C BCG-Nanocage-immunized rhesus macaques before and after Mtb infection. D Changes of IFN-γ+ CD4+ Th1 effector cells in the T cells of bronchoalveolar lavage (BAL) from saline, BCG-immunized and BCG-Nanocage-immunized rhesus macaques before and after Mtb infection, for saline treated macaques, ^^p < 0.01, for BCG vaccined macaques, #p < 0.05, for BCG-Nanocage vaccined macaques, *p < 0.05. Typical flow images for IFN-γ+ CD8+ Th1-like effector cells in T cells in BAL from (E) saline, F BCG-immunized and G BCG-Nanocage-immunized rhesus macaques before and after Mtb infection. H Changes of IFN-γ+ CD8+ Th1-like effector cells in T cells in BAL from saline, BCG-immunized and BCG-Nanocage-immunized rhesus macaques before and after Mtb infection, for saline treated macaques, ^p < 0.05, for BCG vaccined macaques, ##p < 0.01, for BCG-Nanocage vaccined macaques, *p < 0.05

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