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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Nanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection

Fig. 8

BCG-Nanocage immunization confer immune protection against Mtb challenge and alleviate pathological damages in lungs in Mtb-infected non-human primates. A CFU of H37Rv in the right-lower lobes of rhesus macaques. B CFU of H37Rv in the hilar lymph node (HLN) of rhesus macaques. C Typical granuloma observed in the lung of saline-treated but not in BCG- immunized or BCG-Nanocage-immunized rhesus macaques after Mtb challenge. Note that large-scale necrotic granuloma was observed in right lobes of RH #8987 macaques, green arrows indicated the necrotic granuloma. D Typical hematoxylin and eosin (H&E) staining of right lobes of macaques from indicated groups. Note that large-scale necrotic granuloma was observed in right lobes of RH #8987 macaques, green arrows indicated the necrotic granuloma

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Journal of Nanobiotechnology

ISSN: 1477-3155

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