Fig. 6
SPN-PT-based therapeutic effects. A IR thermal images of 143B xenograft mice treated with PBS + 635 nm laser (0.75 W cm−2) (upper row), SPN-SP (100 µg mL−1, 100 µL) + 635 nm laser (0.75 W cm−2) (second row), and SPN-PT (100 µg mL−1, 100 µL) + 635 nm laser (0.75 W cm−2) (lower row) for 6 min. B Corresponding temperature changes in the region of tumors from (A). C Representative morphology images of 143B tumor bearing mice received different treatments on 0 d (upper row) and 15 d (lower row). Scale bar = 1 cm. Monitoring of tumor volumes (D) and body weight of mice F after application of different treatments within the 15 days’ therapeutic procedure. E Representative photograph of tumors excised from mice on 15 d post treatments. G H&E results of tumors obtained from four groups on 24 h post treatments. Scale bar = 200 μm. Data were shown as mean ± SD, n ≥ 3. (p < 0.05, *; p < 0.01, **; p < 0.001, ***; p < 0.0001, ****)