Fig. 6

Mechanistic study of 2D PEG/Cu-BDC nanocatalysts in inducing augmented CDT effect. a The box plot of these 6 samples, in which all samples were almost at the same level, indicating the quality homogenization of the cell samples. b The chart showing the differentially expressed genes in saline- and PEG/Cu-BDC-treated groups (n = 3 biologically independent samples). c The gene expression heat-map of 4T1 cells in saline- and PEG/Cu-BDC-treated groups (n = 3 biologically independent samples). d The gene expression heat-map of the related genes in the ferroptosis and Hedgehog signaling pathways. e, f The top 20 (e) up-regulated, and (f) down-regulated KEGG pathways after treatment with saline and PEG/Cu-BDC nanosheets (P-value < 0.05)