Fig. 5

A Ischemic lesion (white brain region) determined by T2-weighted at 24 h after the treatment administration in the 9 experimental groups: vehicle, vehicle with ultrasound (US), rtPA (1 mg/kg as bolus), rtPA with US (1 mg/kg as bolus), rtPAi (rtPA 10 mg/kg as bolus and infusion), SC@rtPA (1 mg/kg as bolus), SC@rtPA with US (1 mg/kg as bolus), SC@rtPA-G (1 mg/kg as bolus) and SC@rtPA-G with US (1 mg/kg as bolus). B Analysis of the infarct volume at 24 h after treatment administration. The dotted lines represent the median of the vehicle group. The square symbols and empty columns represent the groups treated without ultrasound, while the triangles and colored columns are the groups treated with ultrasound. All data are represented as mean ± SD (n = 5 per group of treatment). In all data statistical analysis was assessed by the one-way ANOVA followed by post-hoc Brown-Forsythe test. *(P < 0.05), ^**(P < 0.01); ^***(P < 0.001)