Fig. 6

A Distribution of microcapsules in the brain analyzed by T2*-weighted images in the different experimental groups at 24 h after the treatment administration. SCs can be identified as hypo-signals (indicated with yellow arrows), mainly, in then ischemic region. B Quantification of the SCs accumulation determined grey value relative to the vehicle group. In each animal three independent measurements were performed. C Quantification of the SCs accumulation by area fraction. D MRI representation of an animal treated with saline (control) and the groups treated with the SCs, in which the hypo-signals could be observed as black spots. All data are represented as mean ± SD (n = 5 per group of treatment and three measurements per animal). In all data statistical analysis was assessed by the one-way ANOVA followed by post-hoc Brown-Forsythe test ***(P < 0.001)