Fig. 1

Identification and characterization of the IM@ZP. A Representative microscopic views of MCN@ZIF-8 under a TEM and DLS analysis for particle size. B The zeta potential of MCN, IR792-MCN, IM@Z and IM@Z -PD-L1 siRNA. C XPS spectrums of IM@Z: C1s spectrum (a), N1s spectrum (b) and Zn 2p spectrum (c). D UV/VIS absorption spectrum of IR792 and IM@ZP. E Gel electrophoresis of PD-L1 siRNA with different mass ratios of IM@Z. F Release curves of siRNA when IM@ZP was incubated with PBS at different pH values. G Stability of PD-L1 siRNA and IM@ZP in serum evaluated by gel electrophoresis