Fig. 9

Mechanism graph. A IM@ZP contains two kinds of photothermal molecules (IR792 and MCN), rendering it enhanced photothermal conversion ability. B ZIF-8 releases siRNA into the cytoplasm in the acidic environment of tumor, showing high-efficiency characteristics to downregulate the expression of PD-L1. Under NIR laser irradiation, IM@ZP effectively kills 4T1 tumor cells, induces DC maturation and cytokine secretion to stimulate immune response