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Table 1 SLPs delivery system and their characteristics

From: Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery

Properties

Lipids

Drugs

Refs.

High drug loading

Oleic acid/linoleic acid/stearic acid/phospholipid

Docetaxel/paclitaxel/5-fluorouracil

[72, 80,81,82]

High intracellular uptake and cytotoxicity

Linoleic acid/palmityl/palmitic acid/linolenic acid

Gemcitabine/doxorubicin

[50, 84, 85, 88, 89]

Enhancing the performance of oral administration

Undecanoate/triglyceride/oleic acid/taurocholic acid/deoxycholic acid

7-Ethyl-10-hydroxycamptothecin/mycophenolic acid/docetaxel/heparin

[95, 97, 109,110,111]

Increasing the antitumor efficacy with low systemic toxicity

Docosahexaenoic acid/oleic acid/linolenic acid/phospholipid

Paclitaxel/cabazitaxel/porphyrin

[46, 75, 101,102,103]