Fig. 2From: A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodiesSequence alignment of the light (A) and heavy (B) chain of humanized anti-TNF-α Abs and the human germline genes. The CDR regions (bold) are defined by Kabat and conserved during the humanization process to increase the diversity of sequences; some key residues were replaced by the germline template (red)Back to article page