Table 1 The wRMSDi of our Remicade humanized candidates and their similarity rankings
From: A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies
Candidates | wRMSDi (Å) | Similarity ranking | EC50 (ng/mL) |
|---|---|---|---|
C1 (A + a) | 1.207 | 1 | 25.83 |
C2 (A + b) | 1.214 | 2 | 26.08 |
B + c | 1.308 | 3 | – |
C3 (B + b) | 1.327 | 4 | 513.65 |
C4 (B + a) | 1.400 | 5 | 545.70 |
A + c | 1.452 | 6 | – |
C + c | 1.453 | 7 | – |
C + a | 1.465 | 8 | – |
C5 (C + b) | 1.469 | 9 | > 1000 |
rRemicade | 1.137 | – | 19.03 |