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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats

Fig. 2

Impaired bone formation in rat bone defect caused by DM-Exos. A N-Exos or DM-Exos were implanted into bone defects of rats that were normal or suffered diabetes mellitus. B Representative micro-CT images within a region of interest (ROI) representing bone defects 2 and 8 weeks after surgery in normal rats and those with diabetes mellitus. n = 5 in each group. C Quantitative analysis of micro-CT imgaes of the new bone formation in bone defects 2 and 8 weeks after transplantation with N-Exos and DM-Exos. BV: bone volume; TV: tissue volume; Tb,N: trabecular number; Tb.Th: trabecular thickness; Tb.Sp: trabecular Spacing. n = 5 in each group; *p < 0.05; **p < 0.01; ***p < 0.001. Data represent means ± SD

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Journal of Nanobiotechnology

ISSN: 1477-3155

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