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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats

Fig. 3

Histological/Immunohistological analysis of bone formation after transplantation of exosomes. A–C Histological analysis of decalcified sections in both normal and diabetic rats. HE/Masson’s/ Safranin O-fast green staining of new bone formation in the bone defect. The black arrow indicates new bone in light pink, blue, or green within the circle, indicating the 3 mm-diameter defect. New bone formation in the bone defects was analyzed using ImageJ software. n = 5 for each group. D–F Immunohistological analysis of the osteoblasts and BMSCs in both normal and diabetic rats. Collagen-1 and CD29/Sca-1 staining of osteoblasts and BMSCs in bone defects. Immunohistochemical staining with IgG was as the control group. Black arrows indicate osteoblasts and BMSCs on the bone surface. n = 5 in each group; *p < 0.05; **p < 0.01; ***p < 0.001. Data represent means ± SD

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Journal of Nanobiotechnology

ISSN: 1477-3155

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