Fig. 5

Diabetes results in changes in the expression of miRNA in BMSCs-Exos. A Differential expression levels of exosomal miRNAs between N-Exos and DM-Exos. MiR-140-3p is an exosomal miRNA that underwent significantly reduced expression in DM-Exos compared with N-Exos. B Differential expression levels of miR-140-3p between N-BMSCs and DM-BMSCs. n = 3 in each group. C Expression levels of miR-140-3p between N-Exos and DM-Exos. n = 3 in each group. D, E MiR-140-3p expression in N-BMSCs/ADSCs and DM-BMSCs/ADSCs, which were treated with N-Exos and DM-Exos. n = 3 in each group. F–I qPCR examination of mRNAs levels of Col-1, Runx-2, ALP, and Sp7 in N-BMSCs and DM-BMSCs after miR-140-3p NC/mimics/inhibitor treatment. n = 3 in each group. J Western blot analysis of Col-1, Runx-2, ALP and Sp7 expression in N-BMSCs and DM-BMSCs after miR-140-3p NC/mimics/inhibitor treatment. n = 3 in each group. *p < 0.05; **p < 0.01; ***p < 0.001. Data represent means ± SD