Fig. 5

In vivo immunomodulatory evaluation. a H&E staining of the air pouches’ skin. b Immunofluorescent staining of air pouches’ skin: green (iNOS), red (Arg-1), and blue (Nucleus). c Fibrous layer thickness of air pouches’ skin. d, e Quantitative analysis of iNOS and Arg-1 in immunofluorescent staining. (n = 3; *, # and + represent P < 0.05 when compared with Ti/SF, Ti/SF/MOF and Ti/SF/I, respectively; **, ## and ++ represent P < 0.01)