Fig. 6

Proof of thrombus theranostic: Monitoring of thrombolysis via molecular ultrasound imaging showed a reduction of thrombus size post administration of TT-MB. A A reduction of thrombus size was observed for animals administered with LIBS-MB and high dose of commercial uPA at 500 U/g BW (black line) as compared to LIBS-MB and saline (blue line) as vehicle control. A reduction of thrombus size was also observed with TT-MB (red line) as compared to LIBS-MB and low dose of commercial uPA at 75 U/g BW (light grey line). B Representative images of baseline versus 45 minutes post-treatment. Baseline area was set to 100% and areas were calculated every 5 min for 45 min. Thrombus size was traced and calculated using VisualSonics software. Treatment groups were compared by use of repeated measures ANOVA over time with Bonferroni post tests at each time point (Mean % ± SEM, (**p < 0.01, ***p < 0.001, n ≥ 3 each) [161]