Fig. 7

Targ-TAP preserves myocardial function and reduces infarct size after I/R. A 4-week post-I/R, EF is preserved in Targ-TAP-treated mice as compared to baseline, Non-Targ-TAP or control-treated mice. Targ-TAP also improved FS and prevented V;d and V;s LV dilatation. B Representative radial strain curves. Colored lines represent the six myocardial regions, black lines represent the average (global) strain. Control mice exhibit a marked decrease in radial strain, both in the infarcted area and globally compared to Targ-TAP. Control mice show significant increases in time for maximum opposite-wall delay as compared to Targ-TAP. C Representative images of Evans Blue/TTC stained hearts 4 weeks post-I/R. Targ-TAP-treated hearts show a reduced I/AaR ratio and infarct size compared to controls. D No difference is observed for bleeding time and blood loss in mice injected with Targ-TAP, compared to control; both are significant increased in mice injected with Eptifibatide. E Targ-TAP did not show a difference in aPTT or PT compared to controls. After normality was confirmed (Anderson–Darling and Shapiro–Wilk tests), one-way or two-way ANOVA with Tukey’s post-hoc test were applied [161]