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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: The effects of extracellular vesicles derived from Krüppel-Like Factor 2 overexpressing endothelial cells on the regulation of cardiac inflammation in the dilated cardiomyopathy

Fig. 4

KLF2-EVs prevented Ly6Chigh monocyte recruitment from bone marrow by inhibiting CCR2 expression. A Representative flow cytometry plots showing Ly6Chigh monocytes (CD11b + Ly6Chigh) in the spleen. B Quantification of Ly6Chigh monocytes in spleen tissues. C Representative flow cytometry plots showing Ly6Chigh monocytes (CD11b + Ly6Chigh) and Ly6Clow monocytes (CD11b + Ly6Clow) in bone marrow. D, E Quantification of Ly6Chigh monocytes (D) and Ly6Clow monocytes in bone marrow. F Representative western blot images of CCR2. G Quantitative analysis of CCR2 protein levels in bone marrow. Representative images of western blots and quantification of CCR2 levels are shown. *P < 0.05, **P < 0.01, ***P < 0.001, ns = not significant

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Journal of Nanobiotechnology

ISSN: 1477-3155

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