Fig. 4

In vivo MRI and PAI performance of CHINPs. A T2-weighted MRI and T2-mapping images of 4T1 tumor-bearing mice at different time points after HINPs, CHINPs injection. B The corresponding Signal intensity values in the tumor region. C In vivo PAI of tumor regions in 4T1 tumor-bearing mice at different time points after HINPs, CHINPs injection and D the corresponding signal intensity values. Data shown are mean ± SD (n = 3). Statistical differences determined by one-way ANOVA; *p < 0.05, ****p < 0.0001