Fig. 3
From: Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice
The biocompatibility and distribution of IONPs for major organs in vivo. a Body weight curves after intravenous injection of IONPs. b, c Cumulative and daily water intake (b) or food consumption (c) after intravenous injection of IONPs. d The distribution of Fe ions in the major organs of ICR mice at 1, 3, 7 and 14 days after initial IONPs exposure. e Histopathological examination of the major organs of ICR mice after intravenous injection of IONPs at various concentrations for 1 day. Scale bar, 100 μm. f, g Alanine aminotransferase (ALT) (f) and aspartate aminotransferase (AST) (g) values of ICR mice for assessing liver function after intravenous injection of IONPs at various concentrations for 1 to 4 weeks. h, i The parameters of renal function including blood urine nitrogen (BUN) (h) and creatinine (CRE) (i) of ICR mice after intravenous injection of IONPs with three concentrations for 1 to 4 weeks. Data were expressed as the Mean ± S.E.M., n = 5