Fig. 6
From: Effects of iron oxide nanoparticles as T2-MRI contrast agents on reproductive system in male mice
The effects of IONPs on epididymides in male ICR mice. a–c Unilateral epididymal index-changing curves (a), accumulation of Fe ions in epididymides evaluated by ICP-AES (b) and histopathological examination of epididymides (c) in ICR mice at 1, 3, 7, 14 and 28 days after intravenous injection of IONPs with various concentrations. Scale bar, 100 μm. d–f The α-GC activity (d) and indexes of oxidative stress in epididymides of ICR mice at 1 day after intravenous injection of IONPs, including MDA (e) and T-SOD (f). Data were expressed as the Mean ± S.E.M., n = 5, **P < 0.01, ***P < 0.001. g TUNEL staining of epididymides from sacrificed ICR mice at 1 day after low-, middle- and high-dose IONPs injection. Apoptotic cells were indicated by arrows. Scale bar, 100 μm