Fig. 3
The distribution of O2-PPSiI in vivo. A The representative images of T1WI and T1 mapping-MRI for the dynamic accumulation of O2-PPSil in tumor. B, C The confirmation of tumor central and peripheral zones based on IVIM-DWI derived f mapping, and significant difference between the outermost segment (“1”) and inner segments (“2–10”) is indicated at P < 0.05 (*) level. (D, E) The dynamic accumulation of O2-PPSil and free Gd-DTPA in the tumor central and peripheral zones monitored, and significant difference between the peripheral and central tumor is indicated at P < 0.05 (*) level. (F, G) The representative images for R2* mapping and the relative changes of R2* value (△R2*) of the whole tumor, central tumor and peripheral tumor in each groups before and after the treatments, and significant difference between the Saline and treatment groups is indicated at P < 0.05 (*) or P < 0.001 (**) level. H Representative immunofluorescence pictures of tumor slices stained with the Anti-HIF-α (green)