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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Hierarchical functional nanoparticles boost osteoarthritis therapy by utilizing joint-resident mesenchymal stem cells

Fig. 5

Therapeutic mechanisms underlying activity of WPV-CuO NPs in OA. a Heatmap of significantly upregulated and downregulated genes between ACLT rats treated by PBS or WPV-CuO NPs. b Volcano plots showing significantly upregulated and downregulated genes following WPV-CuO treatment. Overall, 579 genes were up-regulated and 571 genes were down-regulated. c KEGG pathway enrichment analysis of the 30 most significantly enriched pathways. Immunofluorescent staining of PI3K (d), AKT (e), pAKT (f), and mTOR (g) expressed in cartilage after treatments. These data indicated that WPV-CuO NPs inhibited PI3K/AKT/mTOR pathway in OA model. Scale bar = 100 μm

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Journal of Nanobiotechnology

ISSN: 1477-3155

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