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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: All-in-one theranostic nano-platform based on polymer nanoparticles for BRET/FRET-initiated bioluminescence imaging and synergistically anti-inflammatory therapy for ulcerative colitis

Fig. 1

Preparation of BA/Res@NP-PBP and schematic diagram of targeted delivery of BA/Res@NP-PBP to the inflamed colon. BA and Res were encapsulated into the PLGA core and connected with PLGA-PEG-Mal and PBP. DiL and DiD were co-incorporated in the NPs. Neutrophils and macrophages in inflammatory sites highly expressed MPO, which could combine with luminol to generate blue light. This wavelength could be lengthened and red-shifted to 670 nm through BRET-FRET effect between DiL/DiD-loaded BA/Res@NP-PBP NPs and luminol. The schematic diagram showed an MPO-dependent inflammation imaging via the BRET-FRET effect and a synergistic therapeutic effect between BA and Res for UC

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Journal of Nanobiotechnology

ISSN: 1477-3155

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