Fig. 4
The PGE2 matrix possessed superior therapeutic efficacy for the treatment of HI. A Representative photographs of the ischemic limb, including salvage of the limb, foot necrosis, and loss of the limb on day 14 after ischemic treatment. B Quantification of the percentage of limb loss, foot necrosis, and limb salvage in treatment groups on day 14 (n = 8). C Representative photographs of angiography showing collateral vessel formation at ischemic sites on day 21. Mice were imaged in the prone position (n = 3). D Vascular density was determined by measuring the number of vessels in the unit area. Semiquantitative evaluation of ambulatory impairment (E) and ischemic damage (F) of hindlimb ischemia hindlimbs on day 14 in each group (n = 8). Data are expressed as mean ± SD. *P < 0.05 versus the PGE2 group; #P < 0.05 versus the control group. Hindlimb ischemia mice injected with collagen as a control group