Fig. 7

MSNs-based ultrasound responsive drug delivery. A Schematic of combining MSNs with SSPs. B Representative microscopy images of nanoparticle delivery in the agarose phantom model (MSN in combination with SSPs), showing bright field (left), green fluorescence (center), and green fluorescence in a cross-section of the flow channel (right) (n = 3). Scale bar = 500 µm. Reproduced with permission from Ref. [290] Copyright 2017, Elsevier. C Schematic illustration of the behavior in an aqueous medium of the dual responsive release system. D Release profiles of fluorescein from hybrid-MSNs in PBS solution versus time with ultrasound exposure (10 min and 1.3 MHz, 100 W) (i) and without ultrasound (ii). E Fluorescence microscopy images of LNCaP cells incubated with Rhodamine B-labeled hybrid-MSNs with fluorescein loaded before (top) and after (bottom) ultrasound irradiation. Reproduced with permission from Ref. [17] Copyright 2015, American Chemical Society