Fig. 8

Metallic linkers in MSNs for diverse applications. A Schematic illustration showing the synthesis and cell internalization of designed hierarchical metal-impregnated MSN nanoformulation elucidating the delivery of DOX and plausible mechanism of surpassing MDR. Reproduced with permission from Ref. [82] Copyright 2017, American Chemical Society. B pH-responsive release of DOX from Janus-type (Cu-Fe-MSNs) architectures at various time intervals in simulated fluids, PBS at pH 5.0 and 7.4. compared to naked MSNs. C Cellular internalization illustrating the lysosomal escape of free DOX and Janus-type nanocontainers (Cu-Fe-MSN-DOX) in HeLa cell line and their respective RGB fluorescence intensity profiles of DAPI, LysoTracker, and DOX at the selected region (yellow line) from the samples (i) Free DOX, and (ii) Cu-Fe-MSN-DOX for 2 h, respectively. D CLSM images showing the ROS levels correlating to DCF-DA fluorescence in HeLa cells after treatment with bare MSNs, Cu-MSNs, Fe-MSNs, Cu-Fe-MSNs, and Cu-Fe-MSN-DOX at 80 μg/mL for 3 h. Reproduced with permission from Ref. [92] Copyright 2019, Elsevier