Fig. 9

Schematic illustration of A the dynamic interaction between DOX and benzaldehyde via pH-sensitive benzoic–imine bond. B The synthesis route of M-R@D-PDA-PEG-FA-D and C the combined photothermal chemo gene-targeted therapy of tumors. Reproduced with permission from Ref [318]. Copyright 2017, John Wiley and Sons. D Schematic illustration of the synthesis and cancer cell internalization of the PTX@DMSN@PMAsh-Tf nanocarriers with both tumor-targeting and GSH-responsive deconstruction of the protective PMAsh shell for the efficient delivery of water-insoluble PTX in cancer therapy. Reproduced with permission from Ref. [232] Copyright 2021, Elsevier