Fig. 6

In vivo experiments of Cur@Hb nanoparticles. A Quantitative analysis of the content of intratumor hemoglobin, oxyhemoglobin, and Cur@Hb nanoparticles at different time points. B Tumor volume of nude mice. C Pathological analysis of tumor cells invasion. D Representative images for HIF-1α, CD31, VEGF, Ki67 and TUNEL staining of tumor sections. n = 3, one-way ANOVA followed by Bonferroni post-test, ***p < 0.001