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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation

Fig. 7

BHB alleviates osteolysis in vivo. A Representative image of Micro-CT 3D reconstruction of Calvarium. Scale bar: 5 mm. B Quantification of bone volume to tissue volume ratio (BV/TV), bone mineral density (BMD), total porosity, and the percentage of osteoclast surface per bone surface (OCs/BS). n = 5. C Representative image of TRAP staining. Scale bar: 200 μm. D Representative image of NFATc-1 immunohistochemical staining. Scale bar: 200 μm. E Representative image of MMP9 immunohistochemical staining. F Representative image of CTSK immunohistochemical staining. G Quantification of TRAP-positive cells. H Quantification of NFATc-1 positive cells. I Quantification of MMP9 positive cells. J Quantification of CTSK positive cells. Results are mean ± SEM. #p < .001

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