Fig. 7

NPs affected blood reperfusion of the ischemic hindlimbs. A Schematic diagram of ischaemic hindlimb model construction and VEGF/NGF-NPs promoting angiogenesis. B Intramuscular injection of NPs to target blood flow recovery in ischaemic hindlimb was investigated on 28 days and representative laser doppler perfusion images were presented (n = 5). C Blood flow detected by Laser doppler perfusion at day 1, 7, 14, 21, 28 were analyzed. D Statistical difference of blood flow on 28 d were also showed. The data are presented as mean ± SD (n = 5, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001)