Fig. 2
From: Engineered extracellular vesicles: potentials in cancer combination therapy
Brief biology of exosomes and microvesicles. Exosomes are formed in the endosome circulation as intraluminal vesicles (ILVs), which are derived from the multivesicular endosomes (MVEs). Microvesicles originate by a direct budding at the plasma membrane. After biogenesis, some exosomes and microvesicles will target the recipient cells. Through the binding of receptor and ligand, endocytosis pathway, or direct membrane fusion, exosomes and microvesicles will complete the cargo delivering and intracellular communication mission