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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Cur@SF NPs alleviate Friedreich’s ataxia in a mouse model through synergistic iron chelation and antioxidation

Fig. 3

Iron chelation and antioxidant effect of Cur@SF NPs in vitro. A The relative value of CCK-8 in lymphocytes (GM15850) derived from FRDA patients treated with Cur@SF NPs (NPs) at different concentrations for 1 or 3 days. B The relative levels of mitochondrial LIP (labile iron pool) measured with RPA along with pyridoxal isonicotinoyl hydrazine (PIH) following drug treatment in lymphocytes GM15849 and GM15850. The relative levels of cytosolic LIP measured by calcein-AM along with 2,2′-bipyridyl (BIP) (for details, see “Materials and methods” Section). C The content of malondialdehyde (MDA). D, E The enzymatic activities of SOD and catalase. F, G The activities of mitochondrial complexes I and II. H Cellular ATP content. (*, p < 0.05; **, p < 0.01, GM15850 + NPs vs. GM15850)

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Journal of Nanobiotechnology

ISSN: 1477-3155

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