Fig. 4

Cur@SF NPs increase the behavioral scores of FRDA mice. YG8R mice were intraperitoneally injected with Cur@SF NPs every five days for one month when the mice were 4 months old, and then the behavioral changes were assessed. Y47: KOKI mice containing human FXN as wild type; YG8R: KOKI mice containing human FXN with (GAA)n insert as FRDA model; YG8R + SF: YG8R with silk fibroin administration as a drug delivery vehicle; YG8R + NPs: YG8R mice treated with Cur@SF NPs. A The body weight of mice. The mice were weighed every 15 days during drug administration (n = 10/group). The initial age was 4 months old. B Coordination beam-walk tests. C Coordination rotarod tests. D Strength hang wire tests. E–H Gait tests. The front foot was dyed red, and the rear foot was dyed blue. (*p < 0.05; **p < 0.01; ***p < 0.001; ****,p < 0.0001, YG8R + NPs vs. YG8R)