Fig. 6

Cur@SF NPs eliminate cardiac iron accumulation and reduce oxidative stress levels. All samples were from tissue heart. A Ferrozine assays for iron content. B The relative levels of iron detected with ICP. C Detection of the ferritin protein level. D Prussian staining to detect iron in cardiomyocytes. E Detection of the catalase and SOD2 protein levels. F–H The enzymatic activities of SOD, catalase and MDA content in tissue hearts after Cur@SF NP treatment (n = 5). I Primary macrophages were stained with the green fluorescent dye DCFH-DA after 2 μM Cur@SF NPs treatment for 24 h. (*p < 0.05; **p < 0.01; ***p < 0.001, YG8R + NPs vs. YG8R)