Fig. 8
SPION-mediated magnetic actuation promotes functional and electrophysiological recovery of the sciatic nerve. The SFI was used to assess the functional recovery of nerves at 3 (a), 7 (b), 14 (c), and 21 days (d) after crush injury. The CMAPs (e, g) and MNCV (f, h) were measured using needle electromyography to assess the electrophysiological recovery of the sciatic nerve at 14 and 21 days after crush injury. The boxes in panels a-d show representative footprints. Each experiment was carried out six times. The values are represented as the mean ± SD in all panels except f and h. In panel f and h, the box plot shows the median (whiskers), interquartile ranges (boxes), and 5th–95th percentiles (line); the square represents the mean value, and the triangles represent maximum and minimum. *P < 0.05, **P < 0.01