Fig. 1

Construction and collection of sEV-CUR. a Chondrocyte proliferative ability after treated with different concentrations of curcumin (n = 6); b relative fluorescence units of curcumin were detected before and after ultracentrifugation (n = 3); c relative fluorescence units were detected after curcumin was isolated from sEV by ultracentrifugation (n = 3); d relative fluorescence intensity of sEV and CUR in PBS solution was detected for a 3-h period (n = 3); e relative fluorescence intensity of sEV-CUR and CUR in HA solution was detected for a 3-h period (n = 3). N.S., not significant, *P < 0.05, **P < 0.01, ***P < 0.001