Fig. 5

sEV-CUR exert an enhanced anti-oxidative and anti-apoptosis ability. a, b Immunofluorescence staining and statistical analysis of oxidative stress related marker 8-OHdG in each group (n = 3), scale bar: 50 μm; c MDA level was evaluated in each group (n = 3); d ROS level in each group was detected after curcumin, sEV, or sEV-CUR treatment for 2 days (n = 3); e, f representative images and quantitative analysis of TUNEL staining analysis to detect chondrocyte apoptosis (Red) different groups, scale bar, 50 μm; g, h chondrocyte apoptotic degree in each group was detected and analyzed by flow cytometry assay (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001