Fig. 6
Copyright 2019 American Chemical Society
Immune tolerance can be induced by delivering ovalbumin (OVA) to the liver through PLGA NPs. NPs are decorated with ligands that targets sinusoidal endothelial cells (LSECs) and induce the differentiation of Foxp3+ Treg cells, which can alleviate airway inflammation in OVA sensitized animals. Reprinted with permission [114].