Table 1 Interaction between nanoparticles and monocytes/macrophages

Liposome

siRNA

Inhibiting monocyte production and egression in the bone marrow

Atherosclerosis, myocardial infarction, pancreatic islet transplantation in diabetes

[29]

L-glutamic acid, N-(3-carboxy-1-oxopropyl)-, 1,5-dihexadecyl ester modified liposome

–

Bone marrow accumulation

–

[31]

EGFP-EGF1-conjugated PLGA NPs

shRNA

Modulating macrophage recruitment

Atherosclerosis

[38]

Lipid–polymer NPs

siRNA

Modulating monocyte recruitment

Myocardial infarction

[39]

PLGA NPs

Irbesartan

Modulating monocyte recruitment

Myocardial ischemia–reperfusion injury

[40]

7C1 NPs

siRNA

Modulating monocyte recruitment

Myocardial infarction

[42]

α-gal nanoparticles

–

Modulating macrophage recruitment

Myocardial infarction

[44]

α-gal nanoparticles

–

Modulating macrophage recruitment

Diabetic wound

[45]

Liposomes

Clodronate

Macrophage depletion

Endometriosis

[52]

Liposomes

Clodronate

Macrophage depletion

Rheumatoid arthritis

[53]

Liposomes

Clodronate

Macrophage depletion

Rheumatoid arthritis

[54]

Dendrimer

Methotrexate

Macrophage depletion, anti-inflammation

Rheumatoid arthritis

[56]

Reconstituted high-density lipoprotein NPs

Statins

Inhibiting macrophage proliferation

Atherosclerosis

[57, 58]

Mesoporous silica NPs

IL-4

Modulating macrophage polarization

–

[62]

Gold NPs

–

Modulating macrophage polarization

Bacterial sepsis

[63]

Hyaluronic acid-poly(ethyleneimine) (HA-PEI) NPs

IL-4/IL-10 expressing plasmid DNA

Modulating macrophage polarization

LPS-induced inflammation

[64]

HA-PEI NPs

MicroRNA-223

Modulating macrophage polarization

LPS-induced inflammation

[65]

Graphene oxide NPs

IL-4 expressing plasmid DNA

Modulating macrophage polarization

Myocardial infarction

[66]

Macrophage plasma membrane coated liposomes

Dexamethasone

Selective targeting inflamed tissues

Phlogosis

[69]

Macrophage cell membrane coated PLGA NPs

–

Neutralize endotoxins and proinflammatory cytokines

Sepsis

[79]

Polyion complex NPs

Catalase

Anti-inflammation and improving neuroprotective ability

Parkinson's disease

[73]

Iron oxide NPs

–

Monocyte imaging with MRI

Cutaneous inflammation

[75]

Poly(lactide-coglycolide) NPs

–

Modulating macrophage polarization

Spinal cord injury

[80]