Fig. 8
From: Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents
The mRNA expression of genes in the altered signaling pathways at the end of the dosing and recovery period. The rats were treated with 8 mg/kg LNPs and SNPs for 14 days and allowed to recover for 28 days, and the livers were collected for mRNA quantification by RT-qPCR. A Inflammatory pathways related genes: TNF-α and IL-6. B PPAR signaling pathway related genes: FABP4 and LPL. C Cholesterol and bile acid metabolism pathway-related genes: CYP7A1, CYP7B1, FXR and SHP. D Drug metabolism-cytochrome P450 pathway-related genes: PXR, CYP3A2 and CYP2E1. E Copper ion transport- and metabolism-related gene: metallothionein (MT). Values are represented as the mean ± SD. Statistical significance was assessed using one-way ANOVA (significance versus control: *p < 0.05, **p < 0.01, ***p < 0.001)