Fig. 6
The Antitumor Efficiency for Hepatocellular Carcinoma (Hep 1–6) Cells and Orthotopic Hepatic Tumors. A Flow cytogram representing apoptosis assay based on Annexin V-FITC and propidium iodide staining of 4T1 cells after treatment with different therapeutic groups. B In vivo T1/T2 MRI images for orthotopic hepatic tumor-bearing mice taken at different time points after injection of MnCO3-ICG. Quantification analysis of MRI signal change in C tumor/noise and (D) tumor/liver based on region of interest (ROI) analysis on images from panel B. E Relative luminescence intensity changes based on the bioluminescence images (BLI). F BLI changes after different treatments duration of therapy. G Photographs of representative tumors and (H) H&E-stained tumor sections taken from tumor-bearing mice after various treatments (scale bar: 200 μm)