Fig. 14
From: Application of lipid nanovesicle drug delivery system in cancer immunotherapy
Reprint with permission from [129]. Copyright 2021, Elsevier Ltd
a The design principle of hGLV and the antitumor mechanism of hGLV through PTT combined with immunotherapy. b A typical morphology of hGLV obtained by TEM. c Size distribution of lip, exos and hGLV. d Quantitative of the expression of CD47 on the surface of I/R@hELV and I/R@hGLV by Flow Nano Analyzer. ICD evaluation. e Flow cytometric analysis of CRT exposure on the surface of CT26 cells, f The levels of HMGB1 and g ATP levels in the supernatant of CT26 cells. Antitumor Efficacy of I/R@hGLV plus laser in vivo. h Tumor volume growth curves and (i) Kaplan–Meier survival analysis of the mice bearing CT26 tumors after treatment. Quantitative analysis of DCs maturation in the spleens induced by different treatments on mice bearing CT26 tumors. ***p < 0.001, **p < 0.01, *p < 0.05.