Fig. 3

Catalytic mechanisms of CeO₂ NPs. a Schematic illustration for synthesis of CeO₂@ZIF-8 NPs and its neuroprotective application mechanisms in ischemic stroke mouse model. b, c CeO₂@ZIF-8 reduces infarct volume by reducing ROS-induced oxidative damage in middle cerebral artery occlusion (MCAO) rat model. Reprinted with permission from ref. [28]. Copyright (2020) The American Association for the Advancement of Science. d The recyclable SOD- and CAT-like activity of CeO₂ NPs is mediated by formation of oxygen vacancies and the redox cycling of Ce³⁺ and Ce⁴⁺ in CeO₂ NPs. Reprinted with permission from ref [10].Copyright (2018) American Chemical Society