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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Tumor microenvironment responsive Mn3O4 nanoplatform for in vivo real-time monitoring of drug resistance and photothermal/chemodynamic synergistic therapy of gastric cancer

Fig. 1

The mechanism of pH/H2O2/GSH-responsive MPG NPs as a multifunctional self-enhanced nanoplatform for gastric cancer MDR monitoring and CDT/PTT synergistic therapy. After endocytosis, MPG NPs can react with intracellular GSH by redox reaction to produce Mn2+, which has Fenton-like activity and can convert endogenous H2O2 into highly toxic ·OH under HCO3 conditions. Mn2+ can enhance MRI for in vivo MDR monitoring. Under laser irradiation, MPG NPs can perform CDT/PTT synergistic therapy of MDR in gastric cancer

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